Dimethylformamide and alcohol intolerance.

Dimethylformamide and alcohol intolerance.

Facial flushing and other symptoms were reported by 19 of a group of 102 men who worked with dimethylformamide (DMF). Twenty-six of the 34 episodes occurred after the workers had consumed alcoholic drinks. The metabolite N-methylformamide (MF) was detected in the urine on 45 occasions, the highest recorded concentration being 77 microliter/litre. The highest recorded concentration of DMF in air...

Alcohol intolerance in neoplastic disease.

It has been recognized in recent years that some patients with Hodgkin's disease have pain at the site of disease if they drink alcohol. A mouthful or two of beer or wine may be enough. Other vasodilators have no effect. James (1960) found 58 cases in the literature and suggested an incidence of 17% when patients are specially questioned. Symptoms other than pain (including cough, itching, flus...

[Alcohol intolerance with facial flushing due to topical pimecrolimus treatment].

Toxicological investigations on dimethylformamide.

The boiling point is 1530 C., and it is miscible with water and some organic solvents. On boiling with water or alkali it hydrolyzes to formic acid and dimethylamine. It is more stable than formamide and can be distilled. For the present work freshly distilled dimethylformamide was used and all aqueous solutions were freshly prepared. Dimethylformamide in the atmosphere may be trapped by passin...

Dimethylformamide: an unusual glycosylation modulator.

The key steps in oligosaccharide synthesis are protectinggroup manipulation and stereoselective glycosylation. Various strategies have emerged to expedite glycosylation, and some of these strategies have been elaborated for automated solid-phase synthesis and one-pot cascade glycosylation. Most glycosylation strategies rely on traditional methods for stereochemical control over glycosidic-bond ...